Optimal sensitivity in molecular recognition

Grégoire Bonnet and Albert Libchaber

Physica A: Statistical Mechanics and its Applications, 1999, vol. 263, issue 1, 68-77

Abstract: Molecular recognition of DNA sequences is classically achieved by DNA hybridization of complementary sequences. In the context of mismatch detection, a sequence discrimination sensitivity is defined. Classical denatured DNA probes are compared to molecular beacons (DNA probes with a stemdashloop structure). Molecular beacons are shown to optimize the sequence discrimination sensitivity, by a proper design of the stem length and content. This paper discusses the issue of experimental signal-to-noise in genetic sequence detection, and gives a quantitative analysis and optimization of single-mismatch detection sensitivity.

Keywords: DNA hybridization probe; Molecular beacons; Sequence discrimination sensitivity (search for similar items in EconPapers)
Date: 1999
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:263:y:1999:i:1:p:68-77

DOI: 10.1016/S0378-4371(98)00516-0

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