Complexation of DNA with cationic surfactant

Paulo S. Kuhn, Marcia C. Barbosa and Yan Levin

Physica A: Statistical Mechanics and its Applications, 1999, vol. 269, issue 2, 278-284

Abstract: Transfection of an anionic polynucleotide through a negatively charged membrane is an important problem in genetic engineering. The direct association of cationic surfactant to DNA decreases the effective negative charge of the nucleic acid, allowing the DNA-surfactant complex to approach a negatively charged membrane. The paper develops a theory for solutions composed of polyelectrolyte, salt, and ionic surfactant. The theoretical predictions are compared with the experimental measurements.

Keywords: Thermodynamic functions; Equations of state; Structure of associated liquids; Electrolytes; Molten salts; Macromolecular and polymer solutions; Polymer melts; Swelling (search for similar items in EconPapers)
Date: 1999
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:269:y:1999:i:2:p:278-284

DOI: 10.1016/S0378-4371(99)00184-3

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