Optimization of gene sequences under constant mutational pressure and selection

M. Kowalczuk, A. Gierlik, P. Mackiewicz, S. Cebrat and M.R. Dudek

Physica A: Statistical Mechanics and its Applications, 1999, vol. 273, issue 1, 116-131

Abstract: We have analyzed the influence of constant mutational pressure and selection on the nucleotide composition of DNA sequences of various size, which were represented by the genes of the Borrelia burgdorferi genome. With the help of MC simulations we have found that longer DNA sequences accumulate much less base substitutions per sequence length than short sequences. This leads us to the conclusion that the accuracy of replication may determine the size of genome.

Keywords: DNA; Mutation; Selection; Molecular clock hypothesis (search for similar items in EconPapers)
Date: 1999
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:273:y:1999:i:1:p:116-131

DOI: 10.1016/S0378-4371(99)00346-5

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