Robust and irreversible development in cell society as a general consequence of intra–inter dynamics

Kunihiko Kaneko and Chikara Furusawa

Physica A: Statistical Mechanics and its Applications, 2000, vol. 280, issue 1, 22-33

Abstract: A dynamical systems scenario for developmental cell biology is proposed, based on numerical studies of a system with interacting units with internal dynamics and reproduction. Diversification, formation of discrete and recursive types, and rules for differentiation are found as a natural consequence of such a system. “Stem cells” that either proliferate or differentiate to different types stochastically are found to appear when intra-cellular dynamics are chaotic. Robustness of the developmental process against microscopic and macroscopic perturbations is shown to be a natural consequence of such intra–inter dynamics, while irreversibility in developmental process is discussed in terms of the gain of stability, loss of diversity and chaotic instability.

Keywords: Cell differentiation; Intra–inter dynamics; Irreversibility (search for similar items in EconPapers)
Date: 2000
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:280:y:2000:i:1:p:22-33

DOI: 10.1016/S0378-4371(99)00615-9

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