An unusual antagonistic pleiotropy in the Penna model for biological ageing

A.o Sousa and S Moss de Oliveira

Physica A: Statistical Mechanics and its Applications, 2001, vol. 294, issue 3, 431-438

Abstract: We combine the Penna Model for biological ageing, which is based on the mutation-accumulation theory, with a sort of antagonistic pleiotropy. We show that depending on how the pleiotropy is introduced, it is possible to reproduce both the humans mortality, which increases exponentially with age, and fruitfly mortality, which decelerates at old ages, allowing the appearance of arbitrarily old Methuselah's.

Keywords: Ageing; Penna model; Monte carlo simulations (search for similar items in EconPapers)
Date: 2001
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:294:y:2001:i:3:p:431-438

DOI: 10.1016/S0378-4371(01)00126-1

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