Thermo-kinetic model for Prion diseases

M.l Galdino, S.s de Albuquerque, A.s Ferreira, J.c Cressoni and R.J.v dos Santos

Physica A: Statistical Mechanics and its Applications, 2001, vol. 295, issue 1, 58-63

Abstract: A mean field theory of the auto catalytic Prions conversion reaction is developed under a conservation law for Prions density. These reactions take place in the brain where a normally folded Prion protein (PrPc) is converted into a misfolded, more stable, form (PrPSc). The results reproduce most of the known facts observed in Prion diseases such as: very long incubation time, rapid death after the first symptoms manifestation, dependence of the incubation and death times on the concentration of the initial contamination dose and the existence of a minimum contamination dose for the detection of the disease. Results of computing simulations are also presented.

Keywords: Prion diseases (search for similar items in EconPapers)
Date: 2001
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:295:y:2001:i:1:p:58-63

DOI: 10.1016/S0378-4371(01)00052-8

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