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Aggregation kinetics and structure of cryoimmunoglobulins clusters

M.De Spirito, R Chiappini, F.Andreasi Bassi, E.Di Stasio, B Giardina and G Arcovito

Physica A: Statistical Mechanics and its Applications, 2002, vol. 304, issue 1, 211-219

Abstract: Cryoimmunoglobulins are pathological antibodies characterized by a temperature-dependent reversible insolubility. Rheumatoid factors (RF) are immunoglobulins possessing anti-immunoglobulin activity and usually consist of an IgM antibody that recognizes IgG as antigen. These proteins are present in sera of patients affected by a large variety of different pathologies, such as HCV infection, neoplastic and autoimmune diseases. Aggregation and precipitation of cryoimmunoglobulins, leading to vasculiti, are physical phenomena behind such pathologies. A deep knowledge of the physico-chemical mechanisms regulating such phenomena plays a fundamental role in biological and clinical applications.

Keywords: Physical chemistry of solutions of biological macromolecules; Structure; Bonding; Conformation; Configuration; Isomerism of biomolecules; Disperse systems (search for similar items in EconPapers)
Date: 2002
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:304:y:2002:i:1:p:211-219

DOI: 10.1016/S0378-4371(01)00538-6

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