A linear algebra model for quasispecies

Ricardo Garcı́a-Pelayo

Physica A: Statistical Mechanics and its Applications, 2002, vol. 309, issue 1, 131-156

Abstract: In the present work we present a simple model of the population genetics of quasispecies. We show that the error catastrophe arises because in Biology the mutation rates are almost zero and the mutations themselves are almost neutral. We obtain and discuss previously known results from the point of view of this model. New results are: the fitness of a sequence in terms of its abundance in the quasispecies, a formula for the stable distribution of a quasispecies in which the fitness depends only on the Hamming distance to the master sequence, the time it takes the master sequence to generate a stable quasispecies (such as in the infection by a virus) and the fitness of quasispecies.

Keywords: Quasispecies; Error catastrophe; Multiplicative fitness; Mutation matrices (search for similar items in EconPapers)
Date: 2002
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/S0378437102006295
Full text for ScienceDirect subscribers only. Journal offers the option of making the article available online on Science direct for a fee of $3,000

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:309:y:2002:i:1:p:131-156

DOI: 10.1016/S0378-4371(02)00629-5

Access Statistics for this article

Physica A: Statistical Mechanics and its Applications is currently edited by K. A. Dawson, J. O. Indekeu, H.E. Stanley and C. Tsallis

More articles in Physica A: Statistical Mechanics and its Applications from Elsevier
Bibliographic data for series maintained by Catherine Liu ().