A Fokker–Planck framework in the PolyC:PolyG denaturation

O. Resendis-Antonio

Physica A: Statistical Mechanics and its Applications, 2002, vol. 312, issue 3, 307-314

Abstract: In this work the author presents a Fokker–Planck formalism to describe the denaturation process for simple DNA chains as PolyC:PolyG. This model consists in simulating the denaturation as a diffusion process of a virtual particle moving in an effective external potential. Assuming that such potential is harmonic, we obtain the melting temperature for a PolyC:PolyG chain. Under this assumption the melting temperature Tm, becomes a function of two parameters which specify the nature of the effective potential. The values of the parameters which lead to an agreement between the experimental and theoretical melting temperatures for a PolyC:PolyG chain immersed in a solution of 19.5mM of Na+ and pH 7 are reported.

Date: 2002
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:312:y:2002:i:3:p:307-314

DOI: 10.1016/S0378-4371(02)00982-2

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