Replication associated mutational pressure generating long-range correlation in DNA

Paweł Mackiewicz, Maria Kowalczuk, Dorota Mackiewicz, Aleksandra Nowicka, Małgorzata Dudkiewicz, Agnieszka Łaszkiewicz, Mirosław R. Dudek and Stanisław Cebrat

Physica A: Statistical Mechanics and its Applications, 2002, vol. 314, issue 1, 646-654

Abstract: There are many biological mechanisms which introduce long-range correlations into the DNA molecule. One of the most important is replication of chromosomes, its mechanisms and topology. Replication associated mutational pressure, defined as specific preferences in nucleotide substitutions during replication, generates asymmetry in the genome. On the other hand, substitution rates, which determine the evolutionary turnover time of a nucleotide, are highly correlated with the fraction of that nucleotide in the genome. Assuming the Azbel hypothesis that the number of mutations per genome per generation is invariant and universal, a general rule for mutational pressure can be formulated: the half-time of a nucleotide turnover in the genome is linearly dependent on the number of this nucleotide in the genome.

Keywords: DNA evolution; Replication; Tables of substitutions (search for similar items in EconPapers)
Date: 2002
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/S0378437102011676
Full text for ScienceDirect subscribers only. Journal offers the option of making the article available online on Science direct for a fee of $3,000

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:314:y:2002:i:1:p:646-654

DOI: 10.1016/S0378-4371(02)01167-6

Access Statistics for this article

Physica A: Statistical Mechanics and its Applications is currently edited by K. A. Dawson, J. O. Indekeu, H.E. Stanley and C. Tsallis

More articles in Physica A: Statistical Mechanics and its Applications from Elsevier
Bibliographic data for series maintained by Catherine Liu ().