Improving the realism of the cellular Potts model in simulations of biological cells

Noriyuki Bob Ouchi, James A. Glazier, Jean-Paul Rieu, Arpita Upadhyaya and Yasuji Sawada

Physica A: Statistical Mechanics and its Applications, 2003, vol. 329, issue 3, 451-458

Abstract: Because the extended or cellular large-Q Potts model (CPM) captures effectively the global features of tissue rearrangement experiments, including cell sorting and tissue engulfment, it has become a common technique for cell level simulation of tissues. However, it omits three key elements of real cells, their fixed membrane area, their attractive binding and the dissipation of making and breaking membrane contacts. In this paper, we modify the Hamiltonian to use negative surface energies, constrained surface area and a spin flip energy threshold to improve the correspondence to reality. We find that the new model correctly predicts several dynamical behaviors of cells which the original CPM does not, including the hierarchy of diffusion constants.

Keywords: Potts model; Diffusion; Cell motion (search for similar items in EconPapers)
Date: 2003
References: View complete reference list from CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/S0378437103005740
Full text for ScienceDirect subscribers only. Journal offers the option of making the article available online on Science direct for a fee of $3,000

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:329:y:2003:i:3:p:451-458

DOI: 10.1016/S0378-4371(03)00574-0

Access Statistics for this article

Physica A: Statistical Mechanics and its Applications is currently edited by K. A. Dawson, J. O. Indekeu, H.E. Stanley and C. Tsallis

More articles in Physica A: Statistical Mechanics and its Applications from Elsevier
Bibliographic data for series maintained by Catherine Liu ().