Complexation in polyelectrolyte Solution with divalent surfactants

Marcelo B.A. Silva, Liacir S. Lucena and Marcia C. Barbosa

Physica A: Statistical Mechanics and its Applications, 2004, vol. 331, issue 1, 42-50

Abstract: We study a simple model of DNA divalent cationic surfactant complexation. We find that the combination of electrostatic and hydrophobic effects leads to a cooperative phenomenon in which as the amphiphile is added to the solution containing DNA, a large fraction of the DNA's charge is neutralized by the condensed divalent cationic surfactants, forming the surfoplex. This binding transition occurs for concentrations that are lower for divalent than for monovalent surfactants. Since the electrostatic strength is larger in the first case and the amount of surfactant lower, we suggest that multivalent amphiphilic molecules would be more efficient than monovalent for transfection.

Keywords: DNA; Surfactant; Amphiphiles (search for similar items in EconPapers)
Date: 2004
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:331:y:2004:i:1:p:42-50

DOI: 10.1016/j.physa.2003.07.001

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