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Reversible mesoscopic model of protein adsorption: From equilibrium to dynamics

G.J. Szöllősi, I. Derényi and J. Vörös

Physica A: Statistical Mechanics and its Applications, 2004, vol. 343, issue C, 359-375

Abstract: We present a thermodynamically consistent mesoscopic model of protein adsorption at liquid–solid interfaces. First describing the equilibrium state under varying protein concentration of the solution and binding conditions, we predict a non-trivial (non-monotonic) dependence of the experimentally observable properties of the adsorbed layer (such as the surface density and surface coverage) on these parameters. We subsequently proceed to develop a dynamical model consistent with the equilibrium description, which qualitatively reproduces known experimental phenomena and offers a promising way of studying the exchange of the adsorbed proteins by the proteins of the solution.

Keywords: Protein adsorption; Reversible adsorption; Equilibrium model (search for similar items in EconPapers)
Date: 2004
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:343:y:2004:i:c:p:359-375

DOI: 10.1016/j.physa.2004.06.062

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