Recoiling DNA molecule: simulation and experiment

José Coelho Neto, Ronald Dickman and O.N. Mesquita

Physica A: Statistical Mechanics and its Applications, 2005, vol. 345, issue 1, 173-184

Abstract: Single molecule DNA experiments often generate data from force versus extension measurements involving the tethering of a microsphere to one end of a single DNA molecule while the other is attached to a substrate. We show that the persistence length of single DNA molecules can also be measured based on the recoil dynamics of these DNA-microsphere complexes if appropriate corrections are made to the friction coefficient of the microsphere in the vicinity of the substrate. Comparison between computer simulated recoil curves, generated from the corresponding Langevin equation, and experimental recoils are used to assure the validity of data analysis.

Keywords: DNA; Single molecule; Persistence length; Recoil dynamics (search for similar items in EconPapers)
Date: 2005
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:345:y:2005:i:1:p:173-184

DOI: 10.1016/j.physa.2004.07.029

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