The pulling force of a single DNA molecule condensed by spermidine

Rui Zhang and B.I. Shklovskii

Physica A: Statistical Mechanics and its Applications, 2005, vol. 349, issue 3, 563-570

Abstract: In a recent experiment, a single DNA double helix is stretched and relaxed in the presence of spermidine, a short positive polyelectrolyte, and the pulling force is measured as a function of DNA extension. In a certain range of spermidine concentration, a force plateau appears whose value shows maximum as a function of spermidine concentration. We present a quantitative theory of this plateau force based on the theory of reentrant condensation and derive almost parabolic behavior of the plateau force as a function of the logarithm of the spermidine concentration in the range of condensation. Our result is in good agreement with experimental data.

Keywords: DNA; Spermidine; Condensation; Pulling force (search for similar items in EconPapers)
Date: 2005
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:349:y:2005:i:3:p:563-570

DOI: 10.1016/j.physa.2004.11.013

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