A simulation study on multicomponent lipid bilayer

Srilekha Banerjee and Jayashree Saha

Physica A: Statistical Mechanics and its Applications, 2006, vol. 362, issue 2, 423-432

Abstract: Simulation of a multicomponent lipid bilayer having a fixed percentage of cholesterol is done to study phase transition leading to domain formation. The concept of random lattice has been used in simulation to account for the coupling between the internal and translational degrees of freedom of lipid molecules. Considering a canonical ensemble, dissimilar lipid molecules are allowed to exchange their positions in the lattice subject to standard metropolis algorithm. The steps involved in the process effectively takes into account for the movement of sphingolipids and cholesterol molecules helping formation of cholesterol rich domains of saturated lipids as found in natural membranes.

Keywords: Lipid–cholesterol bilayer; Simulation; Domain formation; Phase diagram (search for similar items in EconPapers)
Date: 2006
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:362:y:2006:i:2:p:423-432

DOI: 10.1016/j.physa.2005.08.017

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