Adhesion between cells, diffusion of growth factors, and elasticity of the AER produce the paddle shape of the chick limb

Nikodem J. Popławski, Maciej Swat, J. Scott Gens and James A. Glazier

Physica A: Statistical Mechanics and its Applications, 2007, vol. 373, issue C, 521-532

Abstract: A central question in developmental biology is how cells interact to organize into tissues? In this paper, we study the role of mesenchyme-ectoderm interaction in the growing chick limb bud using Glazier and Graner's cellular Potts model, a grid-based stochastic framework designed to simulate cell interactions and movement. We simulate cellular mechanisms including cell adhesion, growth, and division and diffusion of morphogens, to show that differential adhesion between the cells, diffusion of growth factors through the extracellular matrix, and the elastic properties of the apical ectodermal ridge together can produce the proper shape of the limb bud.

Keywords: Cellular Potts model; Cell adhesion; Chick limb growth; Apical ectodermal ridge; Fibroblast growth factor; CompuCell3D (search for similar items in EconPapers)
Date: 2007
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Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:373:y:2007:i:c:p:521-532

DOI: 10.1016/j.physa.2006.05.028

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