Transcriptional regulatory network topology from statistics of DNA binding sites

A. Kabakçıoğlu

Physica A: Statistical Mechanics and its Applications, 2007, vol. 386, issue 2, 764-769

Abstract: We show that the out-degree distribution of the gene regulation network of the budding yeast, Saccharomyces cerevisiae, can be reproduced to high accuracy from the statistics of TF binding sequences. Our observation suggests a particular microscopic mechanism for the observed universal global topology in these networks. The numerical data and analytical solution of our model disagree with a simple power-law for the experimentally obtained degree distribution in the case of yeast.

Keywords: Transcriptional regulatory network; Regulatory element; Consensus sequence; Degree distribution (search for similar items in EconPapers)
Date: 2007
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:386:y:2007:i:2:p:764-769

DOI: 10.1016/j.physa.2007.07.013

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