Evolution of gene regulatory networks: Robustness as an emergent property of evolution

Arun Krishnan, Masaru Tomita and Alessandro Giuliani

Physica A: Statistical Mechanics and its Applications, 2008, vol. 387, issue 8, 2170-2186

Abstract: Gene Regulatory Networks (GRNs) have become a major focus of interest in recent years. Although much work has been done in elucidating the transcriptional regulatory network, the underlying mechanisms that have possibly influenced the evolution of these GRNs are still debatable. We have developed a framework to analyze the effect of objective functions, input types and starting populations on the evolution of GRNs with a specific emphasis on the robustness of evolved GRNs.

Keywords: Networks; Gene expression regulation; Computational biology (search for similar items in EconPapers)
Date: 2008
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:387:y:2008:i:8:p:2170-2186

DOI: 10.1016/j.physa.2007.11.022

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