Signal propagation in stem-cell niches

Vladimir P. Zhdanov

Physica A: Statistical Mechanics and its Applications, 2009, vol. 388, issue 18, 3791-3797

Abstract: Stem cells, maintaining tissue homeostasis, are nurtured in microscopic niches formed of so-called environmental cells. The kinetics of proliferation and differentiation of stem cells in such niches depend on their interaction with the messenger proteins secreted by environmental cells. We propose a generic mean-field kinetic model of the propagation of such signals. To motivate our study, we briefly describe a stem-cell niche in the Drosophila ovary. Our model is however applicable to other niches as well. In particular, it helps one to understand the necessary conditions for the niche function. For example, the model predicts that in the case of the Drosophila ovary each germline stem cell should have in the external membrane at least 700 receptors interacting with the signaling Dpp and Gpp proteins emanating from the cap cells.

Keywords: Stem-cell proliferation and differentiation; Environmental cells; Signaling proteins; Protein diffusion; Protein degradation; Receptors; Drosophila ovary; Reaction–diffusion kinetic equations (search for similar items in EconPapers)
Date: 2009
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:388:y:2009:i:18:p:3791-3797

DOI: 10.1016/j.physa.2009.05.040

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