Information propagation from IP3 to target protein: A combined model for encoding and decoding of Ca2+ signal

Qi Zhao, Ming Yi, Kelin Xia and Meng Zhan

Physica A: Statistical Mechanics and its Applications, 2009, vol. 388, issue 19, 4105-4114

Abstract: It is well known that information is encoded in the frequency or amplitude of Ca2+ signal and then decoded by target protein. However, few models considered both the encoding and decoding procedures of Ca2+ signal. In this work, a minimal Li–Rinzel model is coupled with a phosphorylation–dephosphorylation cycle model, which is used to investigate information transmissions from inositol 1,4,5-trisphosphate (IP3) to target proteins and their relations. We found that the mean target protein activity increases with the IP3 concentration, and at a low level of stimulation, the target protein can be more efficiently activated by an oscillatory signal than a constant signal of the same average calcium if Ca2+ acts cooperatively on the kinase. The internal noise resulting from the finite system size is also taken into account in the combined model.

Keywords: Encoding; Decoding; Ca2+ oscillation; Phosphorylation cycle; Combined model; Chemical Langevin method (search for similar items in EconPapers)
Date: 2009
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Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:388:y:2009:i:19:p:4105-4114

DOI: 10.1016/j.physa.2009.06.033

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