Analysis of expression pathways alterations of Arabidopsis thaliana induced by a Necrosis- and Ethylene-inducing protein

Marialva Sinigaglia, Mauro A.A. Castro, Sérgio Echeverrigaray, Gonçalo A.G. Pereira and José C.M. Mombach

Physica A: Statistical Mechanics and its Applications, 2009, vol. 388, issue 20, 4515-4522

Abstract: A major goal in post-genomic biology is the description of physiological functions in terms of gene pathway behavior. In this work, we present the first investigation of expression alterations in ninety-three pathways representing physiological functions of the plant A. thaliana induced by a P. parasitica elicitor (NLPpp) using microarray data publicly available at the AtGenExpress database. Using a novel statistical analysis developed to detect pathway alterations, we identified the gene pathways, hereby called groups of functionally associated genes (defined according to the TAIR/Gene Ontology and other databases), that are significantly altered in response to the elicitor. Instead of looking at individual gene responses, our analysis allowed a detailed characterization of the time ordering of pathways alterations in response to the NLPpp, their physiological implications and specificity. We also observed the activation of genes associated with vesicle trafficking and ROS production implying the initiation of the senescence of the wounded plant tissue.

Keywords: Gene pathways; NLP proteins; Arabidopsis thaliana; Phytophthora parasitica elicitor; Transcriptome analysis; Cell death (search for similar items in EconPapers)
Date: 2009
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:388:y:2009:i:20:p:4515-4522

DOI: 10.1016/j.physa.2009.06.045

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