Channel block-optimized spiking activity of Hodgkin–Huxley neurons on random networks

Yubing Gong, Yinghang Hao and Yanhang Xie

Physica A: Statistical Mechanics and its Applications, 2010, vol. 389, issue 2, 349-357

Abstract: In this paper, we numerically study the effect of channel block on the spiking temporal coherence and spatial synchronization on Hodgkin–Huxley (HH) neuron networks. It is found that under sodium CB the spike coherence is badly reduced, and the synchronization can, depending on the network randomness (the fraction of random shortcuts), be either enhanced or reduced, while, under potassium CB, the spike coherence can be enhanced but the synchronization is reduced. Interestingly, for certain networks of relatively large randomness, the neuron firings can achieve the best temporal coherence at an optimal potassium CB. These results show that under certain conditions channel blocking can increase and optimize the spike coherence and the synchronization on the complex HH neuron networks, whereby the neurons would exhibit a better and the best sub-threshold signal encoding.

Keywords: Neurons; Complex networks; Spike coherence and synchronization; Channel block; Stochastic process (search for similar items in EconPapers)
Date: 2010
References: View complete reference list from CitEc
Citations: View citations in EconPapers (3)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:389:y:2010:i:2:p:349-357

DOI: 10.1016/j.physa.2009.09.033

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