Dynamics of Gompertzian tumour growth under environmental fluctuations

S. Sahoo, A. Sahoo and S.F.C. Shearer

Physica A: Statistical Mechanics and its Applications, 2010, vol. 389, issue 6, 1197-1207

Abstract: We investigate the effect of correlated additive and multiplicative Gaussian white noise on the Gompertzian growth of tumours. Our results are obtained by solving numerically the time-dependent Fokker–Planck equation (FPE) associated with the stochastic dynamics. In our numerical approach we have adopted B-spline functions as a truncated basis to expand the approximated eigenfunctions. The eigenfunctions and eigenvalues obtained using this method are used to derive approximate solutions of the dynamics under study. We perform simulations to analyze various aspects, of the probability distribution, of the tumour cell populations in the transient- and steady-state regimes. More precisely, we are concerned mainly with the behaviour of the relaxation time (τ) to the steady-state distribution as a function of (i) of the correlation strength (λ) between the additive noise and the multiplicative noise and (ii) as a function of the multiplicative noise intensity (D) and additive noise intensity (α). It is observed that both the correlation strength and the intensities of additive and multiplicative noise, affect the relaxation time.

Keywords: Noise; Fluctuation; Tumour cell population; Dynamical probability (search for similar items in EconPapers)
Date: 2010
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:389:y:2010:i:6:p:1197-1207

DOI: 10.1016/j.physa.2009.11.015

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