A model for mesoscale patterns in motile populations

Matthew J. Simpson, Kerry A. Landman, Barry D. Hughes and Anthony E. Fernando

Physica A: Statistical Mechanics and its Applications, 2010, vol. 389, issue 7, 1412-1424

Abstract: Experimental observations of cell migration often describe the presence of mesoscale patterns within motile cell populations. These patterns can take the form of cells moving as aggregates or in chain-like formation. Here we present a discrete model capable of producing mesoscale patterns. These patterns are formed by biasing movements to favor a particular configuration of agent–agent attachments using a binding function f(K), where K is the scaled local coordination number. This discrete model is related to a nonlinear diffusion equation, where we relate the nonlinear diffusivity D(C) to the binding function f. The nonlinear diffusion equation supports a range of solutions which can be either smooth or discontinuous. Aggregation patterns can be produced with the discrete model, and we show that there is a transition between the presence and absence of aggregation depending on the sign of D(C). A combination of simulation and analysis shows that both the existence of mesoscale patterns and the validity of the continuum model depend on the form of f. Our results suggest that there may be no formal continuum description of a motile system with strong mesoscale patterns.

Keywords: Cell motility; Chain migration; Aggregation; Exclusion process; Nonlinear diffusion (search for similar items in EconPapers)
Date: 2010
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/S0378437109010061
Full text for ScienceDirect subscribers only. Journal offers the option of making the article available online on Science direct for a fee of $3,000

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:389:y:2010:i:7:p:1412-1424

DOI: 10.1016/j.physa.2009.12.010

Access Statistics for this article

Physica A: Statistical Mechanics and its Applications is currently edited by K. A. Dawson, J. O. Indekeu, H.E. Stanley and C. Tsallis

More articles in Physica A: Statistical Mechanics and its Applications from Elsevier
Bibliographic data for series maintained by Catherine Liu ().