Frequency–rank correlations of rhodopsin mutations with tuned hydropathic roughness based on self-organized criticality

J.C. Phillips

Physica A: Statistical Mechanics and its Applications, 2012, vol. 391, issue 22, 5473-5478

Abstract: The behavior of disease-linked mutations of membrane proteins is especially simple in rhodopsin, where they are well-studied, as they are responsible for retinitis pigmentosa, RP (retinal degeneration). Here we show that the frequency of occurrence of single RP mutations is strongly influenced by their transportational survival rates, and that this survival correlates well (82%) with a long-range, non-local hydropathic measure of the roughness of the water interfaces of ex-membrane rhodopsin based on self-organized criticality (SOC). It is speculated that this concept may be generally useful in studying survival rates of many mutated proteins.

Keywords: Membrane; Protein; Hydrophobicity; Fold (search for similar items in EconPapers)
Date: 2012
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Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:391:y:2012:i:22:p:5473-5478

DOI: 10.1016/j.physa.2012.06.020

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