Dynamics of macroautophagy: Modeling and oscillatory behavior

Kyungreem Han, Hyun Woong Kwon, Hyuk Kang, Jinwoong Kim, Myung-Shik Lee and M.Y. Choi

Physica A: Statistical Mechanics and its Applications, 2012, vol. 391, issue 3, 686-692

Abstract: We propose a model for macroautophagy and study the resulting dynamics of autophagy in a system isolated from its extra-cellular environment. It is found that the intracellular concentrations of autophagosomes and autolysosomes display oscillations with their own natural frequencies. Such oscillatory behaviors, which are interrelated to the dynamics of intracellular ATP, amino acids, and proteins, are consistent with the very recent biological observations. Implications of this theoretical study of autophagy are discussed, with regard to the possibility of guiding molecular studies of autophagy.

Keywords: Modeling; Numerical simulation; Macroautophagy; Oscillation; Autophagosome; Autolysosome; Protein and organelle; ATP; Amino acid (search for similar items in EconPapers)
Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:391:y:2012:i:3:p:686-692

DOI: 10.1016/j.physa.2011.08.046

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