A complex network analysis of hypertension-related genes

Huan Wang, Chuan-Yun Xu, Jing-Bo Hu and Ke-Fei Cao

Physica A: Statistical Mechanics and its Applications, 2014, vol. 394, issue C, 166-176

Abstract: In this paper, a network of hypertension-related genes is constructed by analyzing the correlations of gene expression data among the Dahl salt-sensitive rat and two consomic rat strains. The numerical calculations show that this sparse and assortative network has small-world and scale-free properties. Further, 16 key hub genes (Col4a1, Lcn2, Cdk4, etc.) are determined by introducing an integrated centrality and have been confirmed by biological/medical research to play important roles in hypertension.

Keywords: Complex network; Hypertension; Integrated centrality; Hub gene (search for similar items in EconPapers)
Date: 2014
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Citations: View citations in EconPapers (2)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:394:y:2014:i:c:p:166-176

DOI: 10.1016/j.physa.2013.09.054

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