The waiting time for a second mutation: An alternative to the Moran model

Rinaldo B. Schinazi

Physica A: Statistical Mechanics and its Applications, 2014, vol. 401, issue C, 224-227

Abstract: The appearance of cancer in a tissue is thought to be the result of two or more successive mutations. We propose a stochastic model that allows for an exact computation of the distribution of the waiting time for a second mutation. This models the time of appearance of the first cancerous cell in a tissue. Our model is an alternative to the Moran model with mutations.

Keywords: Stochastic model; Moran; Mutation; Waiting time (search for similar items in EconPapers)
Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:401:y:2014:i:c:p:224-227

DOI: 10.1016/j.physa.2014.01.031

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