Biophysics of protein–DNA interactions and chromosome organization

John F. Marko

Physica A: Statistical Mechanics and its Applications, 2015, vol. 418, issue C, 126-153

Abstract: The function of DNA in cells depends on its interactions with protein molecules, which recognize and act on base sequence patterns along the double helix. These notes aim to introduce basic polymer physics of DNA molecules, biophysics of protein–DNA interactions and their study in single-DNA experiments, and some aspects of large-scale chromosome structure. Mechanisms for control of chromosome topology will also be discussed.

Keywords: DNA; DNA–protein interactions; Chromosome structure; Chromosome dynamics (search for similar items in EconPapers)
Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:418:y:2015:i:c:p:126-153

DOI: 10.1016/j.physa.2014.07.045

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