Examining a scaled dynamical system of telomere shortening

Benoit M. Cyrenne and Robert J. Gooding

Physica A: Statistical Mechanics and its Applications, 2015, vol. 419, issue C, 268-276

Abstract: A model of telomere dynamics is proposed and examined. Our model, which extends a previously introduced model that incorporates stem cells as progenitors of new cells, imposes the Hayflick limit, the maximum number of cell divisions that are possible. This new model leads to cell populations for which the average telomere length is not necessarily a monotonically decreasing function of time, in contrast to previously published models. We provide a phase diagram indicating where such results would be expected via the introduction of scaled populations, rate constants and time. The application of this model to available leukocyte baboon data is discussed.

Keywords: Telomeres; Hayflick limit; Dynamical modelling (search for similar items in EconPapers)
Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:419:y:2015:i:c:p:268-276

DOI: 10.1016/j.physa.2014.10.047

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