Multistability and sustained oscillations in a model for protein complex formation

Daniel Löb, Christopher Priester and Barbara Drossel

Physica A: Statistical Mechanics and its Applications, 2016, vol. 445, issue C, 85-101

Abstract: We investigate a model for the formation of protein complexes where each protein can occur at most once in a complex. The reaction rates for association and dissociation of proteins can be chosen independently for each reaction, without imposing detailed balance conditions. We show that this simple model can display multistability and periodic oscillations when it contains at least four different protein species. We prove that a system with three elementary species cannot be multistable.

Keywords: Protein complex formation; Chemical reaction network theory; Multistability; Sustained oscillations (search for similar items in EconPapers)
Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:445:y:2016:i:c:p:85-101

DOI: 10.1016/j.physa.2015.10.092

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