Evolution of the ubiquitin-activating enzyme Uba1 (E1)

Douglas C. Allan and J.C. Phillips

Physica A: Statistical Mechanics and its Applications, 2017, vol. 483, issue C, 456-461

Abstract: Ubiquitin tags diseased proteins and initiates an enzyme conjugation cascade, which has three stages. The first-stage enzyme Uba1 (E1) has evolved only modestly from slime mold to humans, and is >14 times larger than Ub. Here we use critical point thermodynamic scaling theory to connect Uba1 (E1) evolution from yeast and slime mold to fruit flies and humans to subtle changes in its amino acid sequences.

Keywords: Enzyme; Self organized criticality; Thermodynamic scaling; Evolution; Allosteric; Unfolding (search for similar items in EconPapers)
Date: 2017
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:483:y:2017:i:c:p:456-461

DOI: 10.1016/j.physa.2017.04.144

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