Bounded noise induced first-order phase transitions in a baseline non-spatial model of gene transcription

d’Onofrio, Alberto, Giulio Caravagna and Sebastiano de Franciscis

Physica A: Statistical Mechanics and its Applications, 2018, vol. 492, issue C, 2056-2068

Abstract: In this work we consider, from a statistical mechanics point of view, the effects of bounded stochastic perturbations of the protein decay rate for a bistable biomolecular network module. Namely, we consider the perturbations of the protein decay/binding rate constant (DBRC) in a circuit modeling the positive feedback of a transcription factor (TF) on its own synthesis. The DBRC models both the spontaneous degradation of the TF and its linking to other unknown biomolecular factors or drugs.

Keywords: First-order phase transitions; Bounded noises; Systems biology; Transcription networks; Hysteresis bifurcation; Noise-induced transitions; Pharmacodynamics; Bistability (search for similar items in EconPapers)
Date: 2018
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Citations: View citations in EconPapers (2)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:492:y:2018:i:c:p:2056-2068

DOI: 10.1016/j.physa.2017.11.123

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