Denoising of genetic switches based on Parrondo’s paradox

Atiyeh Fotoohinasab, Emad Fatemizadeh, Hamid Pezeshk and Mehdi Sadeghi

Physica A: Statistical Mechanics and its Applications, 2018, vol. 493, issue C, 410-420

Abstract: Random decision making in genetic switches can be modeled as tossing a biased coin. In other word, each genetic switch can be considered as a game in which the reactive elements compete with each other to increase their molecular concentrations. The existence of a very small number of reactive element molecules has caused the neglect of effects of noise to be inevitable. Noise can lead to undesirable cell fate in cellular differentiation processes. In this paper, we study the robustness to noise in genetic switches by considering another switch to have a new gene regulatory network (GRN) in which both switches have been affected by the same noise and for this purpose, we will use Parrondo’s paradox. We introduce two networks of games based on possible regulatory relations between genes. Our results show that the robustness to noise can increase by combining these noisy switches. We also describe how one of the switches in network II can model lysis/lysogeny decision making of bacteriophage lambda in Escherichia coli and we change its fate by another switch.

Keywords: Genetic switches; Stochastic simulation; Parrondo’s paradox; Denoising; Cellular differentiation (search for similar items in EconPapers)
Date: 2018
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Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:493:y:2018:i:c:p:410-420

DOI: 10.1016/j.physa.2017.10.009

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