Twisting, supercoiling and stretching in protein bound DNA

Pui-Man Lam and Yi Zhen

Physica A: Statistical Mechanics and its Applications, 2018, vol. 496, issue C, 200-208

Abstract: We have calculated theoretical results for the torque and slope of the twisted DNA, with various proteins bound on it, using the Neukirch–Marko model, in the regime where plectonemes exist. We found that the torque in the protein bound DNA decreases compared to that in the bare DNA. This is caused by the decrease in the free energy g(f), and hence the smaller persistence lengths, in the case of protein bound DNA. We hope our results will encourage experimental investigations of supercoiling in protein bound DNA, which can provide further tests of the Neukirch–Marko model.

Keywords: Supercoiling in DNA; Protein binding to DNA; Plectoneme (search for similar items in EconPapers)
Date: 2018
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:496:y:2018:i:c:p:200-208

DOI: 10.1016/j.physa.2017.12.143

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