Periodic spiking by a pair of ionic channels

L. Ramírez-Piscina and J.M. Sancho

Physica A: Statistical Mechanics and its Applications, 2018, vol. 505, issue C, 345-354

Abstract: Neuronal cells present periodic trains of localized voltage spikes involving a large amount of different ionic channels. A relevant question is whether this is a cooperative effect or it could also be an intrinsic property of individual channels. Here we use a Langevin formulation for the stochastic dynamics of a pair of Na and K ionic channels. These two channels are simple gated pore models where a minimum set of degrees of freedom follow standard statistical physics. The whole system is totally autonomous without any external energy input, except for the chemical energy of the different ionic concentrations across the membrane. As a result it is shown that a unique pair of different ionic channels can sustain membrane potential periodic spikes. The spikes are due to the interaction between the membrane potential, the ionic flows and the dynamics of the internal parts (gates) of each channel structures. The spike involves a series of dynamical steps being the more relevant one the leak of Na ions. Missing spike events are caused by the altered functioning of specific model parts. The time dependent spike structure is comparable with experimental data.

Keywords: Langevin equations; Nonlinear oscillations; Periodic firing; Channel gating (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:505:y:2018:i:c:p:345-354

DOI: 10.1016/j.physa.2018.03.075

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