Thermal-induced folding and unfolding of a transmembrane protein (CorA)

Sunan Kitjaruwankul, Panisak Boonamnaj, Sunita Subedi Paudel, Warin Jetsadawisut, Pornthep Sompornpisut and R.B. Pandey

Physica A: Statistical Mechanics and its Applications, 2018, vol. 506, issue C, 987-992

Abstract: Thermal response of the inner (iCorA) and outer (oCorA) segments of a transmembrane protein CorA is investigated by a large-scale coarse-grained Monte Carlo simulation in native phase. We find that the conformation of iCorA contracts on raising the temperature, in contrast to its thermal response in denatured phase. The conformational response of the oCorA in its native phase appears to be less organized but differs considerably from that in its denatured phase where an abrupt increase of its radius of gyration occurs in a narrow temperature range. The inner segment (iCorA) retains its globular conformation in native phase while oCorA resorts to random-coil configurations with some coagulations on raising the temperature.

Keywords: Coarse-grained model; Protein folding; Monte Carlo simulation; Transmembrane protein CorA; Thermal response (search for similar items in EconPapers)
Date: 2018
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/S0378437118305508
Full text for ScienceDirect subscribers only. Journal offers the option of making the article available online on Science direct for a fee of $3,000

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:506:y:2018:i:c:p:987-992

DOI: 10.1016/j.physa.2018.05.014

Access Statistics for this article

Physica A: Statistical Mechanics and its Applications is currently edited by K. A. Dawson, J. O. Indekeu, H.E. Stanley and C. Tsallis

More articles in Physica A: Statistical Mechanics and its Applications from Elsevier
Bibliographic data for series maintained by Catherine Liu ().