Cooperative fibril model: Native, amyloid-like fibril and unfolded states of proteins

J.S. Espinoza Ortiz and Cristiano L. Dias

Physica A: Statistical Mechanics and its Applications, 2018, vol. 511, issue C, 154-165

Abstract: In this paper, we start by studying the cooperative model of Hansen et al. (1998) which describes folding and unfolding transitions of proteins. Analytical expressions for different thermodynamic quantities are derived, including the degree of thermodynamic cooperativity. This model is then extended to take into account proteins that can aggregate forming amyloid-like fibril structures. Changes to the model were guided by our current understanding of the thermodynamics of fibril formation. We provide analytical equations for different thermodynamic quantities of the modified model and we study its phase diagram as a function of temperature and the binding energy of the protein to the fibril ε⋆. We find that for positive ε⋆ values, fibrils are the most stable state at low temperatures. Moreover, the model predicts that fibrils can coexist with heat unfolded, native, or cold unfolded states.

Keywords: Cooperative fibril model; Native structures; Unfolded structures; Amyloid-like fibril structures; Proteins; Thermostatistics (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:511:y:2018:i:c:p:154-165

DOI: 10.1016/j.physa.2018.07.045

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