SANS study of Amyloid β1−40: Unfolded monomers in DMSO, multidimensional aggregates in water medium

Giulia Festa, Giulia Sancesario, Carmelo Corsaro, Sveva Longo, Domenico Mallamace, Enza Fazio, Laura Arcidiacono, Victoria Garcia Sakai, Roberto Senesi, Giuseppe Sancesario, Francesco Mallamace and Carla Andreani

Physica A: Statistical Mechanics and its Applications, 2019, vol. 517, issue C, 385-391

Abstract: Neurodegenerative diseases such as Alzheimer’s are characterized by neuritic plaques throughout the brain gray matter, associated with neurofibrillary tangles and neuron loss. These plaques are formed by abnormal aggregation of amyloid beta (Aβ) peptide into insoluble fibrils. In the present work we study the Aβ1−40 peptide in the three aggregations states – monomers, oligomers and fibrils – via small angle neutron scattering (SANS) technique. The size of the three forms as well as their fractal nature are investigated at physiologic conditions. Our results evidence that the Aβ1−40 peptide has a good aggregation capability but can also adopt an unfolded conformation in particular conditions, as for example, when incubated in DMSO.

Keywords: SANS; Amyloid fibrils; Amyloid aggregation (search for similar items in EconPapers)
Date: 2019
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:517:y:2019:i:c:p:385-391

DOI: 10.1016/j.physa.2018.11.027

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