Dynamical mechanism of stepping of the molecular motor myosin V along actin filament and simulation in an actual system

Y.C. Chou

Physica A: Statistical Mechanics and its Applications, 2019, vol. 521, issue C, 399-405

Abstract: On the base of the random motion of myosin, the structural asymmetry of the actin filament, and the interaction between the motor and the track, the present study proposes a physical mechanism for the processive stepping of the two-headed molecular motor myosin V along the actin filament. The detachment from actin filament and forward swing of the trailing head, which are caused by increased entropy and the release of the bending energy in the neck region, are the initial steps of the stepping process. The detached head then rotates and randomly moves around the still attached head. A step is completed after the detached head detects the next binding site. In the mechanism, the direction of myosin V movement was determined on the basis of the configuration of the actomyosin system. The role of ATP is the energy provider for the local random motion. The applicability of the dynamic mechanism was evaluated on a simulation system that preserved most of the characteristics of the actomyosin system.

Keywords: Molecular motor; Dynamical mechanism; Myosin/actin; simulation (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
http://www.sciencedirect.com/science/article/pii/S0378437119300755
Full text for ScienceDirect subscribers only. Journal offers the option of making the article available online on Science direct for a fee of $3,000

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:521:y:2019:i:c:p:399-405

DOI: 10.1016/j.physa.2019.01.075

Access Statistics for this article

Physica A: Statistical Mechanics and its Applications is currently edited by K. A. Dawson, J. O. Indekeu, H.E. Stanley and C. Tsallis

More articles in Physica A: Statistical Mechanics and its Applications from Elsevier
Bibliographic data for series maintained by Catherine Liu ().