Forecasting the upper bound free energy difference between protein native-like structures

Jorge A. Vila

Physica A: Statistical Mechanics and its Applications, 2019, vol. 533, issue C

Abstract: Using a combination of statistical thermodynamics and the Gershgorin theorem we computed, in the thermodynamic limit, a plausible value for the upper bound of the free energy difference between native-like structures of monomeric globular proteins. The validity of our result is discussed herein in terms of both the observed free-energy change between the native and denatured states and the micro stability free-energy values obtained from the observed micro-unfolding tendency of nine monomeric globular proteins.

Keywords: Free-energy; Protein; Native states; Gershgorin; Heuristic; Eigenvalues (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:533:y:2019:i:c:s0378437119311975

DOI: 10.1016/j.physa.2019.122053

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