Synchronized attachment and the Darwinian evolution of coronaviruses CoV-1 and CoV-2

J.C. Phillips

Physica A: Statistical Mechanics and its Applications, 2021, vol. 581, issue C

Abstract: CoV2019 has evolved to be much more dangerous than CoV2003. Experiments suggest that structural rearrangements dramatically enhance CoV2019 activity. We identify a new first stage of infection that precedes structural rearrangements by using biomolecular evolutionary theory to identify sequence differences enhancing viral attachment rates. We find a small cluster of mutations which show that CoV-2 has a new feature that promotes much stronger viral attachment and enhances contagiousness. The extremely dangerous dynamics of human coronavirus infection is a dramatic example of evolutionary approach of self-organized networks to criticality. It may favor a very successful vaccine. The identified mutations can be used to test the present theory experimentally.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:581:y:2021:i:c:s0378437121004751

DOI: 10.1016/j.physa.2021.126202

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