Modeling the evolution of membrane during cell adhesion on the nanostructured substrate

Kun Jin, Fang Yuan, Fengting Wang, Bingqi Zhang, Nanxin Li, Tongsheng Chen and Xinlei Li

Physica A: Statistical Mechanics and its Applications, 2024, vol. 635, issue C

Abstract: Using nanostructured substrates for enhancing cell adhesion is an important method. However, the physical mechanism of cell adhesion on nanostructured substrate is not well understood yet, particularly the evolution process of membrane during cell adhesion. Here, we propose an analytical model to study quantitatively the evolution of membrane during adhesion process on the nanostructured substrate. The effects of substrate surface topography, receptor-ligand binding, substrate property and membrane property were investigated. We found a small nanopillar radius, low nanopillar density, large binding rate, large receptor density, low non-specific energy, or large stretching modulus can result in a large adhesion rate and a large adhesion depth. Besides, the evolution of membrane on truncated nanocone arrays was also studied by the model. The theoretical results are in good agreement with the experimental observations, which implied that our studies can provide a useful guide to control cell adhesion process and cell motion on nanostructured substrates.

Keywords: Cell membrane; Nanostructured substrate; Cell adhesion; Receptor-ligand binding; Adhesion energy; Membrane tension; Membrane stretching (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:635:y:2024:i:c:s0378437124000190

DOI: 10.1016/j.physa.2024.129511

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