Antibiotics production of cellulosic waste with solid state fermentation by Streptomyces

S.S. Yang

Renewable Energy, 1996, vol. 9, issue 1, 976-979

Abstract: Cellulosic waste, corncob, was used as a substrate in the production of oxytetracycline by Streptomyces rimosus TM-55 in solid state fermentation. Oxytetracycline was detected on the fourth day, and reached its maximum on the eighth day. During cultivation, the moisture content of substrate increased as incubation being, and pH value increased slightly. Optimal conditions for oxytetracycline production were an initial pH of 5.2 to 6.3, an initial moisture content of 64 to 67%, supplemented with 20% (w/w) rice bran or 1.5 to 2.5% (NH4)2SO4 as the sole nitrogen source, 1.0% CaCO3, 2% MgSO4 7H2O, 0.5% KH2PO4, and 0.6 to 0.8% aspartic acid or lysine, with incubation for 8 days at 25 to 30°C. Each gram of substrate produced 10 to 11 mg of oxytetracycline.

Keywords: Antibiotic production; solid state fermentation; cellulosic waste; Streptomyces; rice bran (search for similar items in EconPapers)
Date: 1996
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Persistent link: https://EconPapers.repec.org/RePEc:eee:renene:v:9:y:1996:i:1:p:976-979

DOI: 10.1016/0960-1481(96)88443-6

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