 The multivariate Wright–Fisher process with mutation: Moment-based analysis and inference using a hierarchical Beta modelAsger Hobolth and Jukka Siren Theoretical Population Biology, 2016, vol. 108, issue C, 36-50 Abstract: We consider the diffusion approximation of the multivariate Wright–Fisher process with mutation. Analytically tractable formulas for the first-and second-order moments of the allele frequency distribution are derived, and the moments are subsequently used to better understand key population genetics parameters and modeling frameworks. In particular we investigate the behavior of the expected homozygosity (the probability that two randomly sampled genes are identical) in the transient and stationary phases, and how appropriate the Dirichlet distribution is for modeling the allele frequency distribution at different evolutionary time scales. We find that the Dirichlet distribution is adequate for the pure drift model (no mutations allowed), but the distribution is not sufficiently flexible for more general mutation models. We suggest a new hierarchical Beta distribution for the allele frequencies in the Wright–Fisher process with a mutation model on the nucleotide level that distinguishes between transitions and transversions. Keywords: Allele frequency; Diffusion; Dirichlet model; Hierarchical Beta; Moments; Multivariate Wright–Fisher (search for similar items in EconPapers) Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:eee:thpobi:v:108:y:2016:i:c:p:36-50 DOI: 10.1016/j.tpb.2015.11.001 Access Statistics for this article Theoretical Population Biology is currently edited by Jeremy Van Cleve More articles in Theoretical Population Biology from Elsevier |
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