Estimation of the HIV-1 backward mutation rate from transmitted drug-resistant strains

J.M. Kitayimbwa, J.Y.T. Mugisha and R.A. Saenz

Theoretical Population Biology, 2016, vol. 112, issue C, 33-42

Abstract: One of the serious threats facing the administration of antiretroviral therapy to human immunodeficiency virus (HIV-1) infected patients is the reported increasing prevalence of transmitted drug resistance. However, given that HIV-1 drug-resistant strains are often less fit than the wild-type strains, it is expected that drug-resistant strains that are present during the primary phase of the HIV-1 infection are replaced by the fitter wild-type strains. This replacement of HIV-1 resistant mutations involves the emergence of wild-type strains by a process of backward mutation. How quickly the replacement happens is dependent on the class of HIV-1 mutation group.

Keywords: Backward mutation rate; Within-host model; HIV-1; Virus mutations; Kaplan–Meier estimates (search for similar items in EconPapers)
Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:eee:thpobi:v:112:y:2016:i:c:p:33-42

DOI: 10.1016/j.tpb.2016.08.001

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