 A nearly-neutral biallelic Moran model with biased mutation and linear and quadratic selectionClaus Vogl and Lynette Caitlin Mikula Theoretical Population Biology, 2021, vol. 139, issue C, 1-17 Abstract: In this article, a biallelic reversible mutation model with linear and quadratic selection is analysed. The approach reconnects to one proposed by Kimura (1979), who starts from a diffusion model and derives its equilibrium distribution up to a constant. We use a boundary-mutation Moran model, which approximates a general mutation model for small effective mutation rates, and derive its equilibrium distribution for polymorphic and monomorphic variants in small to moderately sized populations. Using this model, we show that biased mutation rates and linear selection alone can cause patterns of polymorphism within and substitution rates between populations that are usually ascribed to balancing or overdominant selection. We illustrate this using a data set of short introns and fourfold degenerate sites from Drosophila simulans and Drosophila melanogaster. Keywords: Nearly-neutral theory; Mutation–selection–drift equilibrium; Moran model; McDonald–Kreitman test; Linear and quadratic selection; Mutation bias (search for similar items in EconPapers) Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:eee:thpobi:v:139:y:2021:i:c:p:1-17 DOI: 10.1016/j.tpb.2021.03.003 Access Statistics for this article Theoretical Population Biology is currently edited by Jeremy Van Cleve More articles in Theoretical Population Biology from Elsevier |
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