Selection, recombination, and the ancestral initiation graph

Frederic Alberti, Carolin Herrmann and Ellen Baake

Theoretical Population Biology, 2021, vol. 142, issue C, 46-56

Abstract: Recently, the selection–recombination equation with a single selected site and an arbitrary number of neutral sites was solved by Alberti and Baake (2021) by means of the ancestral selection–recombination graph. Here, we introduce a more accessible approach, namely the ancestral initiation graph. The construction is based on a discretisation of the selection–recombination equation. We apply our method to systematically explain a long-standing observation concerning the dynamics of linkage disequilibrium between two neutral loci hitchhiking along with a selected one. In particular, this clarifies the nontrivial dependence on the position of the selected site.

Keywords: Selection–recombination differential equation; Ancestral initiation graph; Linkage disequilibrium; Hitchhiking; Population genetics (search for similar items in EconPapers)
Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:eee:thpobi:v:142:y:2021:i:c:p:46-56

DOI: 10.1016/j.tpb.2021.08.001

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