 Recombination, gene conversion, and identity-by-descent at three lociDanielle Jones and John Wakeley Theoretical Population Biology, 2008, vol. 73, issue 2, 264-276 Abstract: We investigate the probabilities of identity-by-descent at three loci in order to find a signature which differentiates between the two types of crossing over events: recombination and gene conversion. We use a Markov chain to model coalescence, recombination, gene conversion and mutation in a sample of size two. Using numerical analysis, we calculate the total probability of identity-by-descent at the three loci, and partition these probabilities based on a partial ordering of coalescent events at the three loci. We use these results to compute the probabilities of four different patterns of conditional identity and non-identity at the three loci under recombination and gene conversion. Although recombination and gene conversion do make different predictions, the differences are not likely to be useful in distinguishing between them using three locus patterns between pairs of DNA sequences. This implies that measures of genetic identity in larger samples will be needed to distinguish between gene conversion and recombination. Keywords: Identity-by-descent; Multi-locus identity-by-descent; Coalescent; Gene conversion; Recombination (search for similar items in EconPapers) Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:eee:thpobi:v:73:y:2008:i:2:p:264-276 DOI: 10.1016/j.tpb.2007.10.006 Access Statistics for this article Theoretical Population Biology is currently edited by Jeremy Van Cleve More articles in Theoretical Population Biology from Elsevier |
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